Description
An inhibitor of sarcoplasmic reticulum calcium release (IC50 = 0.3 µM); binds to sarcoplasmic reticulum vesicles isolated from normal and MHS pigs (Kds = 0.3 and 0.09 µM, respectively); reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes (IC50s = 0.42 and 0.19 µM, respectively); reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 µg/ml) and MHS pigs (ED50 = 0.85 mg/kg)